ABSTRACT
Sucralose is a non-nutritive sweetener used in a broad range of foods and beverages. The aim of the study was to demonstrate any histomorphometric changes in liver after sucralose ingestion. Adose of 3g/kg/day of sucralose dissolved in distilled water were given for 30 days to experimental rats by oral gavage whereas Control rats received equal quantity of distilled water. Liver Pieces each having thickness 5mm were taken for paraffin sectioning. 80 slides of 5 micron thick tissue sections were made from each liver and stained with Hematoxylin and Eosin (H & E) which were subsequently evaluated for histomorphometric changes. No significant change in the size of hepatocytes and size of nuclei of hepatocytes were observed between slides of control and sucralose treated rat livers. Sinusoidal width was found to be significantly increased in experimental rat livers as compared to control which is indicative of hepatic damage. A food additive so commonly used as sucralose deserves further investigations.
ABSTRACT
A variant course and branching pattern of the right brachial artery was recorded in a 54-year-old male cadaver during the practical sessions of University College of Medical Sciences, Delhi, India. The right brachial artery divided in the middle third of arm into a medial superficial and lateral deep branch. The superficial medial branch descended anterior to the median nerve and ended by dividing in the cubital fossa into ulnar and radial arteries, whereas the lateral branch descended postero-medial to the median nerve, ending deep to pronator teres as the common interosseous artery. The left brachial artery showed a normal branching pattern by dividing into radial and ulnar arteries in the cubital fossa. The probable origin of such a variation is embryological and familiarity with such variations is imperative as they might affect dynamics of limb function or alter the course of interventional procedures.